SoluProtMutDB

SoluProtMutDB

software

Use of the result by another entity is possible without acquiring a license (the result is not licensed)

The licensor does not require a license fee for the result

Velecký Jan, Ing.
Hamšíková Marie
Štourač Jan
Musil Miloš, Ing., Ph.D. (DIFS)
Damborský Jiří, prof. Mgr., Dr. (UMEL)
Bednář David
Mazurenko Stanislav, Ph.D.

stable data, protein engineering, protein stabilization, stable mutations

SoluProtMutDB is the first database containing data on protein solubility changes
upon mutations. Our database accommodates 33 000 measurements of 17 000 protein
variants in 103 different proteins. The database can serve as an essential source
of information for the researchers designing improved protein variants or those
developing machine learning tools to predict the effects of mutations on
solubility. The database comprises all the previously published solubility
datasets and thousands of new data points from recent publications, including
deep mutational scanning experiments. Moreover, it features many available
experimental conditions known to affect protein solubility. The datasets have
been manually curated with substantial corrections, improving suitability for
machine learning applications. The database is available at
loschmidt.chemi.muni.cz/soluprotmutdb.

Databáze je zdarma dostupná na https://loschmidt.chemi.muni.cz/soluprotmutdb/.

Metody AI pro zabezpečení kybernetického prostoru a řídicí systémy, BUT, Vnitřní projekty VUT, FIT-S-20-6293, start: 2020-03-01, end: 2023-02-28, completed

Department of Information Systems (DIFS)