Product Details

FireProt

Created: 2016

Czech title
FireProt
Type
software
License
Use of the result by another entity is possible without acquiring a license in some cases
License Fee
The licensor does not require a license fee for the result
Authors
Musil Miloš, Ing., Ph.D. (DIFS)
Štourač Jan (FIT)
Bendl Jaroslav, Ing., Ph.D.
Brezovský Jan (FIT)
Martínek Tomáš, doc. Ing., Ph.D. (DCSY)
Zendulka Jaroslav, doc. Ing., CSc. (UIFS)
Prokop Zbyněk (FIT)
Bednář David (FIT)
Damborský Jiří, prof. Mgr., Dr. (UMEL)
Keywords

protein engineering, thermostable proteins, multiple-point mutants, protein stability

Description

FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on integration of structural and evolutionary infromation obtained from several bioinfromatics databases and computational tools. FireProt strategy combines energy and evolution based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FIreProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies. Futhermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format.

Location

Nástroj je dostupný na internetové adrese: http://loschmidt.chemi.muni.cz/fireprot

Projects
Výzkum pokročilých metod ICT a jejich aplikace, BUT, Vnitřní projekty VUT, FIT-S-14-2299, 2014-2016, completed
Research groups
Information and Database Systems Research Group (RG IS)
Departments
Department of Information Systems (DIFS)
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