Publication Details

Genomic PCR simulation with hardware-accelerated approximate sequence matching

LEXA, M.; MARTÍNEK, T.; BECK, P.; FUČÍK, O.; VALLE, G.; ZARA, I. Genomic PCR simulation with hardware-accelerated approximate sequence matching. 21st European Conference on Modelling and Simulation. Praha: European Council for Modelling and Simulation, 2007. p. 333-338. ISBN: 978-0-9553018-2-7.
Czech title
Genomická PCR simulace s hardwarovou akcelerací operace hledani podobnosti
Type
conference paper
Language
English
Authors
Lexa Matej, Ing., Ph.D. (DCSY)
Martínek Tomáš, doc. Ing., Ph.D. (DCSY)
Beck Patrik, Bc.
Fučík Otto, doc. Dr. Ing. (DCSY)
Valle Giorgio
Zara Ivano
Keywords

Virtual PCR; FPGA; sequence alignment; mathematical model

Abstract

We report the latest details on improvements made or planned for theVPCR simulation software currently accessible on the Internet. Wedescribe the inner workings of the dynamic amplification simulationmodel, concentrating mostly on the time- and sensitivity-critical stepof sequence matching. Replacement of BLAST by the more sensitive andfaster PRIMEX similarity search program resulted in a marked improvementof PCR product predictions. Further speed improvements were acheivedusing hardware acceleration of approximate sequence matching.

Published
2007
Pages
333–338
Proceedings
21st European Conference on Modelling and Simulation
Conference
21st European Conference on Modelling and Simulation, Praha, CZ
ISBN
978-0-9553018-2-7
Publisher
European Council for Modelling and Simulation
Place
Praha
BibTeX 
@inproceedings{BUT26056,
  author="Matej {Lexa} and Tomáš {Martínek} and Patrik {Beck} and Otto {Fučík} and Giorgio {Valle} and Ivano {Zara}",
  title="Genomic PCR simulation with hardware-accelerated approximate sequence matching",
  booktitle="21st European Conference on Modelling and Simulation",
  year="2007",
  pages="333--338",
  publisher="European Council for Modelling and Simulation",
  address="Praha",
  isbn="978-0-9553018-2-7"
}
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