Publication Details

A fast all-optical 3D photoacoustic scanner for clinical vascular imaging

HUYNH, N.; ZHANG, E.; FRANCIES, O.; KUKLIŠ, F.; ALLEN, T.; ZHU, J.; ABEYAKOON, O.; LUCKA, F.; BETCKE, M.; JAROŠ, J.; ARRIDGE, S.; COX, B.; PLUMB, A.; BEARD, P. A fast all-optical 3D photoacoustic scanner for clinical vascular imaging. Nature Biomedical Engineering, 2024, vol. 8, no. 10, p. 1-18. ISSN: 2157-846X.
Czech title
Rychlý plně optický 3D fotoakustický skener pro klinické zobrazování cév
Type
journal article
Language
English
Authors
HUYNH, N.
ZHANG, E.
FRANCIES, O.
Kukliš Filip, Ing.
ALLEN, T.
ZHU, J.
ABEYAKOON, O.
LUCKA, F.
BETCKE, M.
Jaroš Jiří, doc. Ing., Ph.D. (DCSY)
ARRIDGE, S.
Cox Ben
PLUMB, A.
BEARD, P.
Keywords

Photoacoustic imaging, Fabry-Perot ultrasound sensor, image reconstruction,
real-time imaging.

Abstract

The clinical assessment of microvascular pathologies (in diabetes and in
inflammatory skin diseases, for example) requires the visualization of
superficial vascular anatomy. Photoacoustic tomography (PAT) scanners based on an
all-optical Fabry-Perot ultrasound sensor can provide highly detailed 3D
microvascular images, but minutes-long acquisition times have precluded their
clinical use. Here we show that scan times can be reduced to a few seconds and
even hundreds of milliseconds by parallelizing the optical architecture of the
sensor readout, by using excitation lasers with high pulse-repetition frequencies
and by exploiting compressed sensing. A PAT scanner with such fast acquisition
minimizes motion-related artefacts and allows for the volumetric visualization of
individual arterioles, venules, venous valves and millimetre-scale arteries and
veins to depths approaching 15mm, as well as for dynamic 3D images of
time-varying tissue perfusion and other haemodynamic events. In exploratory case
studies, we used the scanner to visualize and quantify microvascular changes
associated with peripheral vascular disease, skin inflammation and rheumatoid
arthritis. Fast all-optical PAT may prove useful in cardiovascular medicine,
oncology, dermatology and rheumatology.

Published
2024
Pages
1–18
Journal
Nature Biomedical Engineering, vol. 8, no. 10, ISSN 2157-846X
DOI
10.1038/s41551-024-01247-x
UT WoS
001322478300001
EID Scopus
2-s2.0-85205375842
BibTeX 
@article{BUT189851,
  author="HUYNH, N. and ZHANG, E. and FRANCIES, O. and KUKLIŠ, F. and ALLEN, T. and ZHU, J. and ABEYAKOON, O. and LUCKA, F. and BETCKE, M. and JAROŠ, J. and ARRIDGE, S. and COX, B. and PLUMB, A. and BEARD, P.",
  title="A fast all-optical 3D photoacoustic scanner for clinical vascular imaging",
  journal="Nature Biomedical Engineering",
  year="2024",
  volume="8",
  number="10",
  pages="1--18",
  doi="10.1038/s41551-024-01247-x",
  issn="2157-846X",
  url="https://www.fit.vut.cz/research/publication/12979/"
}
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