FireProt web

FireProt

software

Use of the result by another entity is possible without acquiring a license in some cases

The licensor does not require a license fee for the result

Musil Miloš, Ing., Ph.D. (DIFS)
Štourač Jan
Bendl Jaroslav, Ing., Ph.D.
Brezovský Jan
Martínek Tomáš, doc. Ing., Ph.D. (DCSY)
Zendulka Jaroslav, doc. Ing., CSc. (UIFS)
Prokop Zbyněk
Bednář David
Damborský Jiří, prof. Mgr., Dr. (UMEL)

protein engineering, thermostable proteins, multiple-point mutants, protein
stability

FireProt is a web server for an automated design of thermostable mutants. The
design of thermostable mutants is based on integration of structural and
evolutionary infromation obtained from several bioinfromatics databases and
computational tools.
FireProt strategy combines energy and evolution based approaches together with
several filters that accelerate the calculation by omitting potentially
deleterious mutations. Within its workflow, FireProt integrates 16 computational
tools, utilizing both sequence and structural information in the process.
FIreProt web server provides users with a one-stop-shop solution for the design
of thermostable proteins, constructed by three distinct strategies. Futhermore,
the server allows users to include user-defined mutations into the constructed
thermostable protein and generate corresponding sequences in the FASTA format.

Nástroj je dostupný na internetové adrese: http://loschmidt.chemi.muni.cz/fireprot

Výzkum pokročilých metod ICT a jejich aplikace, BUT, Vnitřní projekty VUT, FIT-S-14-2299, start: 2014-01-01, end: 2016-12-31, completed

Information and Database Systems Research Group (RG IS)

Department of Information Systems (DIFS)