Publication Details

FireProt: web server for automated design of thermostable proteins

MUSIL, M.; MARTÍNEK, T.; ZENDULKA, J. FireProt: web server for automated design of thermostable proteins. DAZ & WIKT 2018 Proceedings. Brno: 2018. p. 1-4.

Type

conference paper

Language

English

Authors

Musil Miloš, Ing., Ph.D. (DIFS)
Martínek Tomáš, doc. Ing., Ph.D. (DCSY)
Zendulka Jaroslav, doc. Ing., CSc. (UIFS)

Annotation

There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. Only a single-point mutations with a small impact on protein stability are typically predicted with the existing tools, while more complex multiple-point mutants are necessary for useful stabilization. Here, we present FireProt, a web server for automated design of multiplepoint thermostable mutants that combines structural and evolutionary information in its calculation core. The server is complemented with interactive, easy-to-use interface that allows users to directly analyze and optionally modify designed thermostable mutants.

Published

2018

Pages

1–4

Proceedings

DAZ & WIKT 2018 Proceedings

Place

Brno

BibTeX

@inproceedings{BUT169466,
  author="Miloš {Musil} and Tomáš {Martínek} and Jaroslav {Zendulka}",
  title="FireProt: web server for automated design of thermostable proteins",
  booktitle="DAZ & WIKT 2018 Proceedings",
  year="2018",
  pages="1--4",
  address="Brno",
  url="https://www.fit.vut.cz/research/publication/11818/"
}