Publication Details

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

CHYRÁ, Z.; ŠEVČÍKOVÁ, T.; VOJTA, P.; PUTEROVÁ, J.; BROŽOVÁ, L.; GROWKOVÁ, K.; FILIPOVÁ, J.; ZÁTOPKOVÁ, M.; GROSICKI, S.; BARCHANICKA, A.; JĘDRZEJCZAK, W.; WASZCZUK-GAJDA, A.; JUNGOVÁ, A.; MIKULÁŠOVÁ, A.; HAJDÚCH, M.; MOKREJŠ, M.; POUR, L.; ŠTORK, M.; HARVANOVÁ, Ľ.; MISTRÍK, M.; MIKALA, G.; ROBAK, P.; CZYŻ, A.; DĘBSKI, J.; USNARSKA-ZUBKIEWICZ, L.; JURCZYSZYN, A.; STEJSKAL, L.; MORGAN, G.; KRYUKOV, F.; BUDINSKÁ, E.; ŠIMÍČEK, M.; JELÍNEK, T.; HRDINKA, M.; HÁJEK, R. Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis. Haematologica, 2021, vol. 106, no. 2, p. 601-604. ISSN: 1592-8721.
Czech title
Heterogenní mutační spektrum a deregulované buněčné dráhy v aberantních plazmatických buňkách podtrhují molekulární patologii primární amyloidózy
Type
journal article
Language
English
Authors
CHYRÁ, Z.
ŠEVČÍKOVÁ, T.
VOJTA, P.
Puterová Janka, Ing., Ph.D. (FIT)
BROŽOVÁ, L.
GROWKOVÁ, K.
FILIPOVÁ, J.
ZÁTOPKOVÁ, M.
GROSICKI, S.
BARCHANICKA, A.
JĘDRZEJCZAK, W.
WASZCZUK-GAJDA, A.
JUNGOVÁ, A.
MIKULÁŠOVÁ, A.
HAJDÚCH, M.
MOKREJŠ, M.
POUR, L.
ŠTORK, M.
HARVANOVÁ, Ľ.
MISTRÍK, M.
MIKALA, G.
ROBAK, P.
CZYŻ, A.
DĘBSKI, J.
USNARSKA-ZUBKIEWICZ, L.
JURCZYSZYN, A.
STEJSKAL, L.
MORGAN, G.
KRYUKOV, F.
BUDINSKÁ, E.
ŠIMÍČEK, M.
JELÍNEK, T.
HRDINKA, M.
HÁJEK, R.
URL
Keywords

amyloidosis, multiple myeloma, clonality, cancer

Abstract

We aim to provide the very first insight into ALA (amyloidosis) +MM (multiple myeloma) molecular profiles and compare the results with ALA and with MM. Our detailed study of ALA and ALA+MM represents an important step towards the improved understanding of their genetic and transcriptomic background, which is a prerequisite for the development of optimal treatment strategies in the future.

Published
2021
Pages
601–604
Journal
Haematologica, vol. 106, no. 2, ISSN 1592-8721
DOI
10.3324/haematol.2019.239756
UT WoS
000615767000010
EID Scopus
2-s2.0-85100634389
BibTeX 
@article{BUT168529,
  author="CHYRÁ, Z. and ŠEVČÍKOVÁ, T. and VOJTA, P. and PUTEROVÁ, J. and BROŽOVÁ, L. and GROWKOVÁ, K. and FILIPOVÁ, J. and ZÁTOPKOVÁ, M. and GROSICKI, S. and BARCHANICKA, A. and JĘDRZEJCZAK, W. and WASZCZUK-GAJDA, A. and JUNGOVÁ, A. and MIKULÁŠOVÁ, A. and HAJDÚCH, M. and MOKREJŠ, M. and POUR, L. and ŠTORK, M. and HARVANOVÁ, Ľ. and MISTRÍK, M. and MIKALA, G. and ROBAK, P. and CZYŻ, A. and DĘBSKI, J. and USNARSKA-ZUBKIEWICZ, L. and JURCZYSZYN, A. and STEJSKAL, L. and MORGAN, G. and KRYUKOV, F. and BUDINSKÁ, E. and ŠIMÍČEK, M. and JELÍNEK, T. and HRDINKA, M. and HÁJEK, R.",
  title="Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis",
  journal="Haematologica",
  year="2021",
  volume="106",
  number="2",
  pages="601--604",
  doi="10.3324/haematol.2019.239756",
  issn="1592-8721",
  url="https://haematologica.org/article/view/9744"
}
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