Publication Details
Semi-quantitative Abstraction and Analysis of Chemical Reaction Networks (Extended Abstract)
KŘETÍNSKÝ, J.
chemical reaction networks, continuous-time Markov chains, population level abstraction, semiquantitative reasoning
Analysis of large continuous-time stochastic systems is a computationally intensive task. In this work we focus on population models arising from chemical reaction networks (CRNs), which play a fundamental role in analysis and design of biochemical systems. Many relevant CRNs are particularly challenging for existing techniques due to complex dynamics including stochasticity, stiffness or multimodal population distributions. We propose a novel approach allowing not only to predict, but also to explain both the transient and steady-state behaviour. It focuses on qualitative description of the behaviour and aims at quantitative precision only in orders of magnitude. First we build a compact understandable model, which we then crudely analyse. As demonstrated on complex CRNs from literature, our approach reproduces the known results, but in contrast to the state-of-the-art methods, it runs with virtually no computational cost and thus offers unprecedented scalability.
@inproceedings{BUT161475,
author="ČEŠKA, M. and KŘETÍNSKÝ, J.",
title="Semi-quantitative Abstraction and Analysis of Chemical Reaction Networks (Extended Abstract)",
booktitle="Proceedings of the 17th International Conference on Computational Methods in Systems Biology",
year="2019",
series="Lecture Notes in Bioinformatics",
pages="337--341",
publisher="Springer International Publishing",
address="Trieste",
doi="10.1007/978-3-030-31304-3\{_}22",
isbn="978-3-030-31303-6",
url="https://www.fit.vut.cz/research/publication/12151/"
}