Publication Details

Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

SUOMI, V.; JAROŠ, J.; TREEBY, B.; CLEVELAND, R. Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney. In 38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC). Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Orlando: Institute of Electrical and Electronics Engineers, 2016. p. 5648-5651. ISBN: 978-1-4577-0220-4.
Czech title
Nelineární 3-D simulace ultrazvukových terapií v ledvinách
Type
conference paper
Language
English
Authors
Suomi Visa (FIT)
Jaroš Jiří, doc. Ing., Ph.D. (DCSY)
Treeby Bradley
Cleveland Robin (FIT)
URL
Keywords

HIFU, k-Wave, ultrasound, kidney, 3D nonlinear simulation

Abstract

Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and sound-speed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0.1 dB. Focal point shifting due to refraction effects resulted in -1.3, 2.6 and 1.3 mm displacements in x-, y-and z-directions respectively. Furthermore, focal point splitting into several smaller subvolumes was observed. The total volume of the secondary focal points was approximately 46% of the largest primary focal point. This could potentially lead to undesired heating outside the target location and longer therapy times.

Published
2016
Pages
5648–5651
Proceedings
38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)
Series
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISBN
978-1-4577-0220-4
Publisher
Institute of Electrical and Electronics Engineers
Place
Orlando
DOI
10.1109/EMBC.2016.7592008
UT WoS
000399823505243
EID Scopus
2-s2.0-85009115346
BibTeX 
@inproceedings{BUT132591,
  author="Visa {Suomi} and Jiří {Jaroš} and Bradley {Treeby} and Robin {Cleveland}",
  title="Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney",
  booktitle="38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)",
  year="2016",
  series="Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
  pages="5648--5651",
  publisher="Institute of Electrical and Electronics Engineers",
  address="Orlando",
  doi="10.1109/EMBC.2016.7592008",
  isbn="978-1-4577-0220-4",
  url="http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615"
}
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