Product Details
AnPaSim v1
Created: 2020
medical device, automated anesthesia, controlled hypotension
AnPaSIM is an extensible pharmacokinetic/pharmacodynamic (PK/PD) discrete time
simulation model. This tool was created as a part of AQUAS research project, in
Medical devices work group developing a device for automated anesthesia during
operations. For this reason, PATMOD is originally focused at anesthesiological
targets and related drugs such as Sodium Nitroprusside, Nitroglycerin and
Rocuronium. We model effects of controlled hypotension and blocking of
neuromuscual transmission (NMT).
AnPaSIM was built to be integrated in a larger distributed simulation
environment, expecting drug dosages on its inputs and outputing body responses to
the anesthesia. PATMOD has fairly general architecture so further PK/PD models
can be added.
Implemented PK/PD models were inspired by current pharmacological, medical and
clinical literature. Unfortunatelly, full validation of the implemented PK/PD
models was not possible due to lack of clinical data. Moreover, human beings
differ widely in their reactions to given drugs. Outputs of the model were at
least confronted to theoretical expectations like half-life characteristic,
expected recovery time (NMT) and so on.
ZDE